Intravenous treatment of postoperative pain in urologic surgery: comparison between analgesics

The need for efficaciously treating acute postoperative pain arises primarily from
the observation that pain is associated with modifications of organs and systems that can
become extremely detrimental to the patients; the antalgic treatment, besides its ethic aspect,
plays therefore an essential role since it can enormously improve the patient’s outcomes,
significantly reducing mortality, morbidity and discomfort.
In the postoperative antalgic therapy, it is possible to associate molecules of different pharmacological
classes: the aim of our study is to compare different combinations between
opioids, Ketorolac and Paracetamol in 75 operations of urologic surgery; to assess any side
effects and the postoperative pain (through the VNS scale) and, if necessary, to administer
supplementary doses of Tramadol in order to complete the pre-arranged pain therapy.
The statistical analysis of data demonstrates first how different antalgic medicaments can
enhance each other, highlighting the greater effectiveness of Ketorolac compared to Paracetamol
during the awakening period, at the pre-established dosages.
Moreover, the study presents the slight occurrence of side effects during the postoperative
period, of no importance in most cases: we can therefore come to the conclusion that the
association between different drugs could result in a reduction in the single given dosages,
and would probably be co-responsible of the low incidence of iatrogenic sequelae.